Article
Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation.
Cold Spring Harbor perspectives in medicine - 3 Oct 2016
Shetzer Yoav, Molchadsky Alina, Rotter Varda
Abstract excerpt
More than half of human tumors harbor an inactivated p53 tumor-suppressor gene. It is well accepted that mutant p53 shows an oncogenic gain-of-function (GOF) activity that facilitates the transformed phenotype of cancer cells. In addition, a growing body of evidence supports the notion that cancer stem cells comprise a seminal constituent in the initiation and progression of cancer development. Here, we elaborate...
Topics
- Animals
- Antineoplastic Agents
- Gain of Function Mutation
- Humans
- Mice
- Molecular Targeted Therapy
- Neoplasms
- Neoplastic Stem Cells
- Phenotype
- Tumor Suppressor Protein p53