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Therapeutic targeting of the p53 pathway in cancer stem cells

24 Sept 2012

Abstract excerpt

INTRODUCTION: Cancer stem cells (CSCs) are a high profile drug target for cancer therapeutics due to their indispensable role in cancer progression, maintenance and therapeutic resistance. Restoring wild-type (WT) p53 function is an attractive new therapeutic approach for the treatment of cancer due to the well-described powerful tumor suppressor function of p53. As emerging evidence intimately links p53 and stem...

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PMID: 22998602
DOI: 10.1517/14728222.2012.726985

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