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Article

Regulation of self‐renewal in normal and cancer stem cells

28 Jul 2012

Abstract excerpt

Mutations can confer a selective advantage on specific cells, enabling them to go through the multistep process that leads to malignant transformation. The cancer stem cell hypothesis postulates that only a small pool of low-cycling stem-like cells is necessary and sufficient to originate and develop the disease. Normal and cancer stem cells share important functional similarities such as 'self-renewal' and...

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PMID: 22846222
DOI: 10.1111/j.1742-4658.2012.08727.x

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