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Article

A new role for p53 in maintaining genetic stability in embryonic stem cells.

Cell cycle (Georgetown, Tex.) - 1 Mar 2005

Xu Yang

Abstract excerpt

Embryonic stem cells (ESCs) are capable of unlimited self-renewal and retain the pluripotency to differentiate into all cell lineages in the body. Since DNA damage occurs during normal cellular proliferation as well as after exposure to DNA damaging agents, it is critical for ESCs to possess stringent mechanisms to maintain genetic stability and prevent the passage of DNA damage to the progeny. Consistent with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15701975
DOI: 10.4161/cc.4.3.1529

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