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p53: The barrier to cancer stem cell formation

19 Feb 2014

Abstract excerpt

The role of p53 as the "guardian of the genome" in differentiated somatic cells, triggering various biological processes, is well established. Recent studies in the stem cell field have highlighted a profound role of p53 in stem cell biology as well. These studies, combined with basic data obtained 20 years ago, provide insight into how p53 governs the quantity and quality of various stem cells, ensuring a...

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PMID: 24560790
DOI: 10.1016/j.febslet.2014.02.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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