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Article

The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis.

Scientific reports - 27 Jan 2021

Hodeify Rawad, Dib Maya, Alcantara-Adap Ethel, Courjaret Raphael, Nader Nancy, Reyes Cleo Z, Hammad Ayat S, Hubrack Satanay, Yu Fang, Machaca Khaled

Abstract excerpt

Regulation of Ca2+ signaling is critical for the progression of cell division, especially during meiosis to prepare the egg for fertilization. The primary Ca2+ influx pathway in oocytes is Store-Operated Ca2+ Entry (SOCE). SOCE is tightly regulated during meiosis, including internalization of the SOCE channel, Orai1. Orai1 is a four-pass membrane protein with cytosolic N- and C-termini. Orai1 internalization...

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Identifiers

PMID: 33504898
DOI: 10.1038/s41598-021-82048-z
PMCID: PMC7840751

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