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TMCO1 is essential for ovarian follicle development by regulating ER Ca2+ store of granulosa cells

21 Feb 2018

Abstract excerpt

TMCO1 (transmembrane and coiled-coil domains 1) is an endoplasmic reticulum (ER) transmembrane protein that actively prevents Ca 2+ stores from overfilling. To characterize its physiological function(s), we generated Tmco1 −/− knockout (KO) mice. In addition to the main clinical features of human cerebrofaciothoracic (CFT) dysplasia spectrum, Tmco1 −/− females manifest gradual loss of ovarian follicles, impaired...

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PMID: 29467381
DOI: 10.1038/s41418-018-0067-x

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