Article
Synergistic effect of concurrent high molecular risk mutations and lower JAK2 mutant variant allele frequencies on prognosis in patients with myelofibrosis-insights from a multicenter study.
Leukemia - 1 Jan 2025
Wang Yu-Hung, Wei Chao-Hung, Lin Chien-Chin, Gurnari Carmelo, Awada Hussein, Benajiba Lina, Daltro de Oliveira Rafael, Soret-Dulphy Juliette, Cassinat Bruno, Zucenka Andrius, Mosquera Orgueira Adrián, Yuan Chang-Tsu, Lee Sze-Hwei, Yao Chi-Yuan, Gurashi Kristian, Hou Hsin-An, Batta Kiran, Pérez Encinas Manuel Mateo, Chou Wen-Chien, Maciejewski Jaroslaw P, Wiseman Daniel H, Kiladjian Jean-Jacques, Tien Hwei-Fang
Abstract excerpt
In addition to high-molecular risk (HMR) mutations (ASXL1, EZH2, SRSF2, IDH, and U2AF1Q157), lower JAK2V617F variant allele frequencies (VAF) have been demonstrated to be associated with poor prognosis of myelofibrosis (MF) patients. Nevertheless, the relationship between JAK2V617F VAF and HMR mutations remains inconclusive. To address this, we analyzed the mutation status of 54 myeloid neoplasm-relevant genes...
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