Distinct Longitudinal Changes in EEG Measures Reflecting Functional Network Disruption in ALS Cognitive Phenotypes.

doi:10.1007/s10548-024-01078-8

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Distinct Longitudinal Changes in EEG Measures Reflecting Functional Network Disruption in ALS Cognitive Phenotypes.

Brain topography - 4 Oct 2024

Metzger Marjorie, Dukic Stefan, McMackin Roisin, Giglia Eileen, Mitchell Matthew, Bista Saroj, Costello Emmet, Peelo Colm, Tadjine Yasmine, Sirenko Vladyslav, McManus Lara, Buxo Teresa, Fasano Antonio, Chipika Rangariroyashe, Pinto-Grau Marta, Schuster Christina, Heverin Mark, Coffey Amina, Broderick Michael, Iyer Parameswaran M, Mohr Kieran, Gavin Brighid, Pender Niall, Bede Peter, Muthuraman Muthuraman, Hardiman Orla, Nasseroleslami Bahman

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is characterised primarily by motor system degeneration, with clinical evidence of cognitive and behavioural change in up to 50% of cases. We have shown previously that resting-state EEG captures dysfunction in motor and cognitive networks in ALS. However, the longitudinal development of these dysfunctional patterns, especially in networks linked with cognitive-behavioural...

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PMID: 39367160
DOI: 10.1007/s10548-024-01078-8
PMCID: PMC11452478

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