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Article

Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice

16 Mar 2015

Abstract excerpt

Intervertebral disc (IVD) degeneration is a common degenerative disease, yet much is unknown about the mechanisms during its pathogenesis. Herein we investigated whether progranulin (PGRN), a chondroprotective growth factor, is associated with IVD degeneration. PGRN was detectable in both human and murine IVD. The levels of PGRN were upregulated in murine IVD tissue during aging process. Loss of PGRN resulted in...

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PMID: 25777988
DOI: 10.1038/srep09102

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