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Article

Impaired Intervertebral Disc Development and Premature Disc Degeneration in Mice With Notochord‐Specific Deletion of CCN2

9 Jul 2013

Abstract excerpt

OBJECTIVE: Currently, our ability to treat intervertebral disc (IVD) degeneration is hampered by an incomplete understanding of disc development and aging. The specific function of matricellular proteins, including CCN2, during these processes remains an enigma. The aim of this study was to determine the tissue-specific localization of CCN proteins and to characterize their role in IVD tissues during embryonic...

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PMID: 23839921
DOI: 10.1002/art.38075

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