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Article

Role of HMOX1 Promoter Genetic Variants in Chemoresistance and Chemotherapy Induced Neutropenia in Children with Acute Lymphoblastic Leukemia.

International journal of molecular sciences - 20 Jan 2021

Bukowska-Strakova Karolina, Włodek Joanna, Pitera Ewelina, Kozakowska Magdalena, Konturek-Cieśla Anna, Cieśla Maciej, Gońka Monika, Nowak Witold, Wieczorek Aleksandra, Pawińska-Wąsikowska Katarzyna, Józkowicz Alicja, Siedlar Maciej

Abstract excerpt

Whilst the survival rates of childhood acute lymphoblastic leukemia (ALL) have increased remarkably over the last decades, the therapy resistance and toxicity are still the major causes of treatment failure. It was shown that overexpression of heme oxygenase-1 (HO-1) promotes proliferation and chemoresistance of cancer cells. In humans, the HO-1 gene (HMOX1) expression is modulated by two polymorphisms in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33498175
DOI: 10.3390/ijms22030988
PMCID: PMC7863945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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