Article
A C-terminal amphipathic helix is necessary for the in vivo tubule-shaping function of a plant reticulon.
Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2016
Breeze Emily, Dzimitrowicz Natasha, Kriechbaumer Verena, Brooks Rhiannon, Botchway Stanley W, Brady Jacob P, Hawes Chris, Dixon Ann M, Schnell Jason R, Fricker Mark D, Frigerio Lorenzo
Abstract excerpt
Reticulons (RTNs) are a class of endoplasmic reticulum (ER) membrane proteins that are capable of maintaining high membrane curvature, thus helping shape the ER membrane into tubules. The mechanism of action of RTNs is hypothesized to be a combination of wedging, resulting from the transmembrane topology of their conserved reticulon homology domain, and scaffolding, arising from the ability of RTNs to form...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
