Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.

doi:10.1212/WNL.0000000000011555

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Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.

Neurology - 30 Mar 2021

Georgakis Marios K, Harshfield Eric L, Malik Rainer, Franceschini Nora, Langenberg Claudia, Wareham Nicholas J, Markus Hugh S, Dichgans Martin

Abstract excerpt

OBJECTIVE: We employed Mendelian randomization to explore the effects of genetic predisposition to type 2 diabetes (T2D), hyperglycemia, insulin resistance, and pancreatic β-cell dysfunction on risk of stroke subtypes and related cerebrovascular phenotypes. METHODS: We selected instruments for genetic predisposition to T2D (74,124 cases, 824,006 controls), HbA1c levels (n = 421,923), fasting glucose levels (n =...

Topics

Atrophy
Blood Glucose
Brain
Carotid Artery Diseases
Cerebral Hemorrhage
Cerebrovascular Disorders
Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Glycated Hemoglobin
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hyperglycemia

Insulin Resistance

Insulin-Secreting Cells

Ischemic Stroke

Mendelian Randomization Analysis

White Matter

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Identifiers

PMID: 33495378
DOI: 10.1212/WNL.0000000000011555
PMCID: PMC8055310

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