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Article

Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease

23 Apr 2018

Abstract excerpt

Background and Purpose— The relationship between type 2 diabetes mellitus (T2D) and cerebral small vessel disease (CSVD) is unclear. We aimed to examine the causal effect of T2D, fasting glucose levels, and higher insulin resistance on CSVD using Mendelian randomization. Methods— Five CSVD phenotypes were studied; 2 were clinical outcomes associated with CSVD (lacunar stroke: n=2191/27 297 and intracerebral...

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Share to Cerebrovascular and genetic disorders
Share to Genetic Associations and Epidemiology
Share to Intracerebral and Subarachnoid Hemorrhage Research

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PMID: 29686024
DOI: 10.1161/strokeaha.117.020536

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