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Article

Hedgehog Signaling in Pancreatic Fibrosis and Cancer

1 Mar 2016

Abstract excerpt

The hedgehog signaling pathway was first discovered in the 1980s. It is a stem cell-related pathway that plays a crucial role in embryonic development, tissue regeneration, and organogenesis. Aberrant activation of hedgehog signaling leads to pathological consequences, including a variety of human tumors such as pancreatic cancer. Multiple lines of evidence indicate that blockade of this pathway with several...

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Share to Epigenetics and DNA Methylation
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PMID: 26962810
DOI: 10.1097/md.0000000000002996

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