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Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver

27 Feb 2017

Abstract excerpt

Irisin is secreted by skeletal muscle during exercise and influences energy and metabolic homeostasis. This hormone is a cleaved and secreted fragment of fibronectin type III domain-containing 5 (FNDC5). Elucidation of the FNDC5 gene regulation mechanism is necessary to clarify the function of irisin as a potential therapeutic target in human metabolic diseases. Thus, we investigated the genetic and epigenetic...

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PMID: 28240298
DOI: 10.1038/srep43296

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Glucocorticoid receptor positively regulates transcription of FNDC5 in the liverPMID 28240298Read ↗

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