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Article

Impact of APOE ε4 genotype on initial cognitive symptoms differs for Alzheimer's and Lewy body neuropathology.

Alzheimer's research & therapy - 23 Jan 2021

Pillai Jagan A, Bena James, Bonner-Jackson Aaron, Leverenz James B

Abstract excerpt

BACKGROUND: APOE ε4 carrier status is known to increase odds of amnestic presentations with Alzheimer's pathology. It is unknown how APOE ε4 carrier status impacts odds of specific initial cognitive symptoms in the presence of Lewy body pathology. Here we evaluate the impact of APOE ε4 genotype on initial cognitive symptoms among those with Alzheimer's disease pathology (ADP) and Lewy-related pathology (LRP)....

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Source

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Identifiers

PMID: 33485373
DOI: 10.1186/s13195-021-00771-1
PMCID: PMC7825215

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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