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Article

Structural basis for potency differences between GDF8 and GDF11

3 Mar 2017

Abstract excerpt

BACKGROUND: Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members of the transforming growth factor β (TGFβ) family. While GDF8 has been recognized as a negative regulator of muscle growth and differentiation, there are conflicting studies on the function of GDF11 and whether GDF11 has beneficial effects on age-related dysfunction. To address whether GDF8 and GDF11 are functionally...

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PMID: 28257634
DOI: 10.1186/s12915-017-0350-1

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