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Article

A variant of human growth differentiation factor-9 that improves oocyte developmental competence.

The Journal of biological chemistry - 5 Jun 2020

Stocker William A, Walton Kelly L, Richani Dulama, Chan Karen L, Beilby Kiri H, Finger Bethany J, Green Mark P, Gilchrist Robert B, Harrison Craig A

Abstract excerpt

Growth differentiation factor-9 (GDF9) and bone morphogenetic protein-15 (BMP15) are co-expressed exclusively in oocytes throughout most of folliculogenesis and play central roles in controlling ovarian physiology. Although both growth factors exist as homodimers, recent evidence indicates that GDF9 and BMP15 can also heterodimerize to form the potent growth factor cumulin. Within the cumulin complex, BMP15...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32350111
DOI: 10.1074/jbc.RA120.013050
PMCID: PMC7278348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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