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Article

Homologous recombination deficiency: how genomic signatures are generated.

Current opinion in genetics & development - 1 Feb 2021

Setton Jeremy, Reis-Filho Jorge S, Powell Simon N

Abstract excerpt

Cancer genomes harbor mutational and structural rearrangements that are jointly shaped by DNA damage and repair mechanisms. Accumulating evidence suggests that genetic alterations in DNA repair-defective tumors reflect the scars caused by the use of backup DNA repair mechanisms needed to maintain cellular viability. Detailed analysis of the patterns of mutations and structural rearrangements present in...

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Source

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Identifiers

PMID: 33477018
DOI: 10.1016/j.gde.2021.01.002
PMCID: PMC8377996

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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