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Article

Frequency and prognostic value of mutations associated with the homologous recombination DNA repair pathway in a large pan cancer cohort.

Scientific reports - 19 Nov 2020

Principe Daniel R, Narbutis Matthew, Koch Regina, Rana Ajay

Abstract excerpt

PARP inhibitors have shown remarkable efficacy in the clinical management of several BRCA-mutated tumors. This approach is based on the long-standing hypothesis that PARP inhibition will impair the repair of single stranded breaks, causing synthetic lethality in tumors with loss of high-fidelity double-strand break homologous recombination. While this is now well accepted and has been the basis of several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33214570
DOI: 10.1038/s41598-020-76975-6
PMCID: PMC7677533

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