Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.

doi:10.1038/ng.2007.41

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Article

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.

Nature genetics - 1 Jan 2008

Jaeger Emma, Webb Emily, Howarth Kimberley, Carvajal-Carmona Luis, Rowan Andrew, Broderick Peter, Walther Axel, Spain Sarah, Pittman Alan, Kemp Zoe, Sullivan Kate, Heinimann Karl, Lubbe Steven, Domingo Enric, Barclay Ella, Martin Lynn, Gorman Maggie, Chandler Ian, Vijayakrishnan Jayaram, Wood Wendy, Papaemmanuil Elli, Penegar Steven, Qureshi Mobshra, Farrington Susan, Tenesa Albert, Cazier Jean-Baptiste, Kerr David, Gray Richard, Peto Julian, Dunlop Malcolm, Campbell Harry, Thomas Huw, Houlston Richard, Tomlinson Ian

Abstract excerpt

We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that in...

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Identifiers

PMID: 18084292
DOI: 10.1038/ng.2007.41

Genes

GREM1
SCG5
FMN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18084292-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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