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Article

Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.

BMC medical genetics - 14 Feb 2011

Niittymäki Iina, Tuupanen Sari, Li Yilong, Järvinen Heikki, Mecklin Jukka-Pekka, Tomlinson Ian P M, Houlston Richard S, Karhu Auli, Aaltonen Lauri A

Abstract excerpt

BACKGROUND: Common single-nucleotide polymorphisms (SNPs) in ten chromosomal loci have been shown to predispose to colorectal cancer (CRC) in genome-wide association studies. A plausible biological mechanism of CRC susceptibility associated with genetic variation has so far only been proposed for three loci, each pointing to variants that affect gene expression through distant regulatory elements. In this study,...

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Identifiers

PMID: 21314996
DOI: 10.1186/1471-2350-12-23
PMCID: PMC3045878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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