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The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis

13 Oct 2010

Abstract excerpt

BACKGROUND: Among the most harmful of all genetic abnormalities that appear in colorectal cancer (CRC) development are mutations of KRAS and its downstream effector BRAF as they result in abnormal extracellular signal-related kinase (ERK) signaling. In a previous report, we had shown that expression of a constitutive active mutant of MEK1 (caMEK) in normal rat intestinal epithelial cells (IECs) induced...

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PMID: 20942929
DOI: 10.1186/1476-4598-9-271

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