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Constitutive activation of the MEK/ERK pathway inhibits intestinal epithelial cell differentiation

8 Jul 2011

Abstract excerpt

The Ras/Raf/MEK/ERK cascade regulates intestinal epithelial cell proliferation. Indeed, while barely detectable in differentiated cells of the villi, ERK1/2-activated forms are detected in the nucleus of undifferentiated human intestinal crypt cells. In addition, we and others have reported that ERKs are selectively inactivated during enterocyte differentiation. However, whether inactivation of the ERK pathway is...

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PMID: 21737780
DOI: 10.1152/ajpgi.00508.2010

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