Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene.

doi:10.1016/0896-6273(92)90024-8

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Article

Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene.

Neuron - 1 Oct 1992

Luo L, Tully T, White K

Abstract excerpt

Drosophila amyloid precursor protein-like (Appl) gene encodes a protein product (APPL) similar to beta-amyloid precursor protein (APP) associated with Alzheimer's disease. To understand the in vivo function of APPL protein, we have generated flies deleted for the Appl gene. These flies are viable, fertile, and morphologically normal, yet they exhibit subtle behavioral deficits. We show that a fast phototaxis...

Topics

Amyloid beta-Protein Precursor
Animals
Animals, Genetically Modified
Blotting, Western
Chromosome Mapping
Crosses, Genetic
DNA
Drosophila melanogaster
Female
Gene Deletion
Genotype
Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Light

Male

Motor Activity

Recombinant Fusion Proteins

X Chromosome

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Open in PubMed

Identifiers

PMID: 1389179
DOI: 10.1016/0896-6273(92)90024-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1389179-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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