Article
Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma in Col4a1 Mutant Mice.
Investigative ophthalmology & visual science - 1 Oct 2015
Mao Mao, Smith Richard S, Alavi Marcel V, Marchant Jeffrey K, Cosma Mihai, Libby Richard T, John Simon W M, Gould Douglas B
Abstract excerpt
PURPOSE: Mutations in the gene encoding collagen type IV alpha 1 (COL4A1) cause multisystem disorders including anterior segment dysgenesis (ASD) and optic nerve hypoplasia. The penetrance and severity of individual phenotypes depends on genetic context. Here, we tested the effects of a Col4a1 mutation in two different genetic backgrounds to compare how genetic context influences ocular dysgenesis, IOP, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.