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Entropy-driven catalytic amplification adjusted by stoichiometry for single-nucleotide variants detection with high abundance sensitivity.

Analytica chimica acta - 8 Feb 2021

Tan Yun, Zhang Xiaohui, Tang Weiyang, Zhong Weiye, Fan Jin, Guo Donghua, Wu Xiaolong, Liu Yizhen

Abstract excerpt

Single-nucleotide variants (SNV) detection with high abundance sensitivity is of great significance in clinical application, molecular diagnostics and biological research. In this study, a high abundance sensitivity SNV detection strategy based on entropy-driven catalytic (EDC) amplification adjusted by stoichiometry is proposed. In EDC, the toehold exchange reaction is used to initiate subsequent catalytic...

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PMID: 33453878
DOI: 10.1016/j.aca.2020.12.023

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