Article
FcεR1-expressing nociceptors trigger allergic airway inflammation.
The Journal of allergy and clinical immunology - 1 Jun 2021
Crosson Theo, Wang Jo-Chiao, Doyle Benjamin, Merrison Hannah, Balood Mohammad, Parrin Alexandre, Pascal Maud, Mindt Barbara C, Seehus Corey R, Ozcan Alp, Huang Xuan, Semenara Elise, Lai Nicole Y Y, Majdoubi Abdelilah, Abdulnour Raja-Elie E, Rajchgot Trevor, Rafei Moutih, Foster Simmie L, Thibodeau Jacques, Fritz Jörg H, Levy Bruce D, Woolf Clifford J, Talbot Sebastien
Abstract excerpt
BACKGROUND: Lung nociceptor neurons amplify immune cell activity and mucus metaplasia in response to an inhaled allergen challenge in sensitized mice. OBJECTIVE: We sought to identify the cellular mechanisms by which these sensory neurons are activated subsequent to allergen exposure. METHODS: We used calcium microscopy and electrophysiologic recording to assess whether vagal neurons directly respond to the model...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.