Article
Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma.
Respiratory research - 2 Jun 2016
Baker Katie, Raemdonck Kristof, Dekkak Bilel, Snelgrove Robert J, Ford John, Shala Fisnik, Belvisi Maria G, Birrell Mark A
Abstract excerpt
BACKGROUND: Asthma prevalence has increased world-wide especially in children; thus there is a need to develop new therapies that are safe and effective especially for patients with severe/refractory asthma. CD4(+) T cells are thought to play a central role in disease pathogenesis and associated symptoms. Recently, TRPV1 has been demonstrated to regulate the activation and inflammatory properties of CD4(+) cells....
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