Identification of a Neuroimmune Circuit that Regulates Allergic Inflammation in the Esophagus

Abstract excerpt

Eosinophilic esophagitis is a chronic food antigen-driven allergic inflammatory disease associated with symptoms involving the nervous system such as refractory pain. Yet, the role of the nervous system in disease pathogenesis has not received much attention. Herein, we demonstrate that allergen exposure evokes pain-like behavior in association with increased nociceptor signaling and transcriptional responses in d...

Topics

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• Afferent Pathways
• Allergens
• Central Nervous System
• Enteric Nervous System
• Eosinophilic Esophagitis
• Hypersensitivity
• Neurons
• Phenotype

Identifiers and source

Literature Corpus work

07364de0-3a3a-5c5f-93f0-87b1cf2339e9

DOI

10.1101/2024.11.16.623883