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Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway.

Experimental cell research - 1 Jul 2023

Liu Shenglan, Wu Junhong, Lu Xiaolu, Guo Caiyao, Zheng Qisheng, Wang Yu, Hu Qiao, Bian Shuigen, Luo Li, Cheng Qilai, Liu Zhiping, Dai Wei

Abstract excerpt

Colorectal cancer (CRC) is the second most common cause of cancer-related mortality and lies third in terms of morbidity due to the limited number of effective druggable targets. Since cancer stem cells (CSCs) are considered to be one of the roots of tumorigenesis, outgrowth and metastasis, targeting CSCs may be a promising strategy to reverse the malignant phenotypes of CRC. Cyclin-dependent kinase 12 (CDK12)...

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Identifiers

PMID: 37100369
DOI: 10.1016/j.yexcr.2023.113613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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