Article
Cancer-initiating cells derived from human rectal adenocarcinoma tissues carry mesenchymal phenotypes and resist drug therapies.
Cell death & disease - 3 Oct 2013
Fan C-W, Chen T, Shang Y-N, Gu Y-Z, Zhang S-L, Lu R, OuYang S-R, Zhou X, Li Y, Meng W-T, Hu J-K, Lu Y, Sun X-F, Bu H, Zhou Z-G, Mo X-M
Abstract excerpt
Accumulating evidence indicates that cancer-initiating cells (CICs) are responsible for cancer initiation, relapse, and metastasis. Colorectal carcinoma (CRC) is typically classified into proximal colon, distal colon, and rectal cancer. The gradual changes in CRC molecular features within the bowel may have considerable implications in colon and rectal CICs. Unfortunately, limited information is available on CICs...
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