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Cancer stem cell–associated miRNAs serve as prognostic biomarkers in colorectal cancer

21 Mar 2019

Abstract excerpt

Chemoresistance in cancer is linked to a subset of cancer cells termed "cancer stem cells" (CSCs), and in particular, those expressing the CD44 variant appear to represent a more aggressive disease phenotype. Herein, we demonstrate that CD44v6 represents a CSC population with increased resistance to chemotherapeutic agents, and its high expression is frequently associated with poor overall survival (OS) and...

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PMID: 30895943
DOI: 10.1172/jci.insight.125294

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