Article
Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes.
EBioMedicine - 1 Jan 2021
Garcia-Bates Tatiana M, Palma Mariana L, Anderko Renee R, Hsu Denise C, Ananworanich Jintanat, Korber Bette T, Gaiha Gaurav D, Phanuphak Nittaya, Thomas Rasmi, Tovanabutra Sodsai, Walker Bruce D, Mellors John W, Piazza Paolo A, Kroon Eugene, Riddler Sharon A, Michael Nelson L, Rinaldo Charles R, Mailliard Robbie B
Abstract excerpt
BACKGROUND: During early HIV-1 infection, immunodominant T cell responses to highly variable epitopes lead to the establishment of immune escape virus variants. Here we assessed a type 1-polarized monocyte-derived dendritic cell (MDC1)-based approach to selectively elicit cytotoxic T lymphocyte (CTL) responses against highly conserved and topologically important HIV-1 epitopes in HIV-1-infected individuals from...
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