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Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo

13 Jan 2021

Abstract excerpt

Burkholderia cenocepacia (B. cenocepacia) is an opportunistic bacterium; causing severe life threatening systemic infections in immunocompromised individuals including cystic fibrosis patients. The lack of gasdermin D (GSDMD) protects mice against endotoxin lipopolysaccharide (LPS) shock. On the other hand, GSDMD promotes mice survival in response to certain bacterial infections. However, the role of GSDMD during...

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PMID: 33441602
DOI: 10.1038/s41598-020-79201-5

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