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Contribution of the Type 6 Secretion System to Apoptosis and Macrophage Polarization During <i>Burkholderia pseudomallei</i> Infection

2024-03-03

Abstract excerpt

Burkholderia pseudomallei ( Bpm ) is the causative agent of the disease melioidosis. As a facultative intracellular pathogen, Bpm has a complex lifestyle that culminates in cell-to-cell fusion and multinucleated giant cells (MNGCs) formation. The virulence factor responsible for MNGC formation is the type 6 secretion system (T6SS), a contractile nanomachine. MNGC formation is a cell-to-cell spread strategy that...

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Literature Corpus work
a3e6a287-865b-55a0-8485-f6f98e45298a
DOI
10.1101/2024.03.01.583019
Open publication

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