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Article

Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages.

Journal of leukocyte biology - 1 Mar 2011

Kotrange Sheetal, Kopp Benjamin, Akhter Anwari, Abdelaziz Dalia, Abu Khweek Arwa, Caution Kyle, Abdulrahman Basant, Wewers Mark D, McCoy Karen, Marsh Clay, Loutet Slade A, Ortega Ximena, Valvano Miguel A, Amer Amal O

Abstract excerpt

Burkholderia cenocepacia infections in CF patients involve heightened inflammation, fatal sepsis, and high antibiotic resistance. Proinflammatory IL-1β secretion is important in airway inflammation and tissue damage. However, little is known about this pathway in macrophages upon B. cenocepacia infection. We report here that murine macrophages infected with B. cenocepacia K56-2 produce proinflammatory cytokine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21178113
DOI: 10.1189/jlb.0910513
PMCID: PMC3040464

Genes

CFTR
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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