Article

Constraint-based analysis for causal discovery in population-based biobanks

2019-03-04

Abstract excerpt

Availability of large genetic databases has led to the development of powerful causal inference methods that use genetic variables as instruments to estimate causal effects. Such methods typically make many assumptions about the underlying causal graphical model, are limited in the patterns they search for in the data, and there is no guide for systematic analysis of a large database. Here, we present cGAUGE, a ne...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da80c8e7-aa6c-5127-95aa-4c8d55ae8215
DOI: 10.1101/566133

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Constraint-based analysis for causal discovery in population-based biobanksDOI 10.1101/566133Read

Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks.Semantic proximity Read

Causal inference for multiple risk factors and diseases from genomics dataSemantic proximity Read

Assessment and visualization of phenome-wide causal relationships using genetic data: an application to dental caries and periodontitis.Semantic proximity Read

Inference and visualization of phenome-wide causal relationships using genetic data: an application to dental caries and periodontitisSemantic proximity Read

The Causal Pivot: A structural approach to genetic heterogeneity and variant discovery in complex diseases.Semantic proximity Read

The Causal Pivot: A Structural Approach to Genetic Heterogeneity and Variant Discovery in Complex DiseasesSemantic proximity Read

Causal inference for heritable phenotypic risk factors using heterogeneous genetic instrumentsSemantic proximity Read

Causal inference for heritable phenotypic risk factors using heterogeneous genetic instruments.Semantic proximity Read

Using genetic data to strengthen causal inference in observational research.Semantic proximity Read

Direct causal variable discovery leveraging the invariance principle: application in biomedical studiesSemantic proximity Read

Generating a robust statistical causal structure over 13 cardiovascular disease risk factors using genomics data.Semantic proximity Read

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individualsSemantic proximity Read