Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic evolution of antibiotic resistance is contingent on genetic background following a long-term experiment with Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2021

Card Kyle J, Thomas Misty D, Graves Joseph L, Barrick Jeffrey E, Lenski Richard E

Abstract excerpt

Antibiotic resistance is a growing health concern. Efforts to control resistance would benefit from an improved ability to forecast when and how it will evolve. Epistatic interactions between mutations can promote divergent evolutionary trajectories, which complicates our ability to predict evolution. We recently showed that differences between genetic backgrounds can lead to idiosyncratic responses in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Evolution, Molecular

Share to Genes, Bacterial

Share to Genome, Bacterial

Share to Genomics

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 33441451
DOI: 10.1073/pnas.2016886118
PMCID: PMC7865137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic evolution of antibiotic resistance is contingent on genetic background following a long-term experiment with Escherichia coli.PMID 33441451Read ↗

Historical contingency in the evolution of antibiotic resistance after decades of relaxed selection.Semantic proximity Read ↗

Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli.Semantic proximity Read ↗

Understanding, predicting and manipulating the genotypic evolution of antibiotic resistance.Semantic proximity Read ↗

Experimental evolution as an efficient tool to dissect adaptive paths to antibiotic resistance.Semantic proximity Read ↗

From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic ResistanceSemantic proximity Read ↗

High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli.Semantic proximity Read ↗

High-Throughput Evolution Unravels Landscapes of High-Level Antibiotic Resistance Induced by Low-Level Antibiotic ExposureSemantic proximity Read ↗

Evolutionary Pathways and Trajectories in Antibiotic Resistance.Semantic proximity Read ↗

Genome-wide analysis captures the determinants of the antibiotic cross-resistance interaction network.Semantic proximity Read ↗

Evolutionary history and genetic parallelism affect correlated responses to evolution.Semantic proximity Read ↗

Predictable Phenotypes of Antibiotic Resistance Mutations.Semantic proximity Read ↗

Environmental and genetic modulation of the phenotypic expression of antibiotic resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.