Article
Environmental and genetic modulation of the phenotypic expression of antibiotic resistance.
FEMS microbiology reviews - 1 May 2017
Hughes Diarmaid, Andersson Dan I
Abstract excerpt
Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene, and generally an acquired mechanism results in a predictable increase in phenotypic resistance. However, recent findings suggest that the environment and/or the genetic context can modify the phenotypic expression of specific resistance genes/mutations. An important implication from these findings is that a given...
Topics
- Adaptation, Physiological
- Anti-Bacterial Agents
- Bacteria
- Biofilms
- Drug Resistance, Multiple, Bacterial
- Environment
- Gene Transfer, Horizontal
- Genotype
- Humans
- Mutation
- Phenotype