Article
Expression and Activity of the Small RhoGTPase Cdc42 in Blood Cells of Older Adults Are Associated With Age and Cardiovascular Disease.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Sept 2017
Florian Maria Carolina, Klenk Jochen, Marka Gina, Soller Karin, Kiryakos Hady, Peter Richard, Herbolsheimer Florian, Rothenbacher Dietrich, Denkinger Michael, Geiger Hartmut
Abstract excerpt
The small RhoGTPase Cdc42 is mechanistically linked to aging of multiple tissues and to rejuvenation of hematopoietic stem cells in mice. However, data validating Cdc42 activity and expression as biomarker for aging in humans are still missing. Here, we hypothesized that Cdc42 might serve as a novel biomarker of aging in older adults and therefore we determined Cdc42 activity and expression levels in peripheral...
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