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Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium.

Ecotoxicology and environmental safety - 15 Mar 2021

Ma Yu, Liang Yuehui, Liang Ningjuan, Zhang Yujing, Xiao Fang

Abstract excerpt

Hexavalent chromium [Cr(VI)] is a common heavy metal pollutant that can cause a number of human disease, including inflammation and cancer. Senescent cells can secrete a variety of molecules known as senescence-associated secretory phenotype (SASP). Our previous studies have confirmed that Cr(VI) can induce premature senescence in L02 hepatocytes, but the composition and the function of the related SASP are still...

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PMID: 33440265
DOI: 10.1016/j.ecoenv.2021.111908

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