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Article

NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn's disease.

Nature communications - 11 Jan 2021

Rochereau Nicolas, Roblin Xavier, Michaud Eva, Gayet Rémi, Chanut Blandine, Jospin Fabienne, Corthésy Blaise, Paul Stéphane

Abstract excerpt

Intestinal microfold cells are the primary pathway for translocation of secretory IgA (SIgA)-pathogen complexes to gut-associated lymphoid tissue. Uptake of SIgA/commensals complexes is important for priming adaptive immunity in the mucosa. This study aims to explore the effect of SIgA retrograde transport of immune complexes in Crohn's disease (CD). Here we report a significant increase of SIgA transport in CD...

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Identifiers

PMID: 33431850
DOI: 10.1038/s41467-020-20348-0
PMCID: PMC7801705

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