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Article

Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study

9 Jan 2021

Abstract excerpt

OBJECTIVE: To investigate which cardiometabolic factors underlie clustering of osteoarthritis (OA) with cardiovascular disease, and the extent to which these mediate an effect of education. DESIGN: Genome-wide association study (GWAS) of OA was performed in UK Biobank (60,800 cases and 328,251 controls) to obtain genetic association estimates for OA risk. Genetic instruments and association estimates for body...

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PMID: 33422704
DOI: 10.1016/j.joca.2020.12.015

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