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Article

The impact of education inequality on rheumatoid arthritis risk is mediated by smoking and body mass index: Mendelian randomization study.

Rheumatology (Oxford, England) - 5 May 2022

Zhao Sizheng Steven, Holmes Michael V, Zheng Jie, Sanderson Eleanor, Carter Alice R

Abstract excerpt

OBJECTIVE: To estimate the causal relationship between educational attainment-as a proxy for socioeconomic inequality-and risk of RA, and quantify the roles of smoking and BMI as potential mediators. METHODS: Using the largest genome-wide association studies (GWAS), we performed a two-sample Mendelian randomization (MR) study of genetically predicted educational attainment (instrumented using 1265 variants from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34436562
DOI: 10.1093/rheumatology/keab654
PMCID: PMC9071527

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