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Article

CYP51A polymorphisms of Aspergillus fumigatus in lung transplant recipients: Prevalence, correlation with phenotype, and impact on outcomes.

Medical mycology - 6 Jul 2021

Henry Benoît, Guenette Alexis, Cheema Faiqa, Pérez-Cortés Armelle, McTaggart Lisa, Mazzulli Tony, Singer Lianne, Keshavjee Shaf, Kus Julianne V, Husain Shahid

Abstract excerpt

Azole resistance in Aspergillus fumigatus is increasing worldwide and can affect prognosis. It is mostly mediated by cytochrome P51 (CYP51) mutations. In lung transplant recipients (LTR), little is known regarding the prevalence and clinical impact of CYP51 mutations. One hundred thirty-one consecutive A. fumigatus isolates from 103 patients were subjected to CYP51A genotyping through PCR and sequencing....

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PMID: 33418565
DOI: 10.1093/mmy/myaa110

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