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Article

cyp51A-Based mechanisms of Aspergillus fumigatus azole drug resistance present in clinical samples from Germany.

Antimicrobial agents and chemotherapy - 1 Aug 2013

Bader Oliver, Weig Michael, Reichard Utz, Lugert Raimond, Kuhns Martin, Christner Martin, Held Jürgen, Peter Silke, Schumacher Ulrike, Buchheidt Dieter, Tintelnot Kathrin, Groß Uwe

Abstract excerpt

Since the mid-1990s, a steady increase in the occurrence of itraconazole-resistant Aspergillus fumigatus isolates has been observed in clinical contexts, leading to therapeutic failure in the treatment of aspergillosis. This increase has been predominantly linked to a single allele of the cyp51A gene, termed TR/L98H, which is thought to have arisen through the use of agricultural azoles. Here, we investigated the...

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Identifiers

PMID: 23669382
DOI: 10.1128/AAC.00167-13
PMCID: PMC3719746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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