Article
Incidence of Cyp51 A key mutations in Aspergillus fumigatus-a study on primary clinical samples of immunocompromised patients in the period of 1995-2013.
PloS one - 1 Jan 2014
Spiess Birgit, Postina Patricia, Reinwald Mark, Cornely Oliver A, Hamprecht Axel, Hoenigl Martin, Lass-Flörl Cornelia, Rath Peter-Michael, Steinmann Jörg, Miethke Thomas, Lauten Melchior, Will Silke, Merker Natalia, Hofmann Wolf-Karsten, Buchheidt Dieter
Abstract excerpt
As the incidence of azole resistance in Aspergillus fumigatus is rising and the diagnosis of invasive aspergillosis (IA) in immunocompromised patients is rarely based on positive culture yield, we screened our Aspergillus DNA sample collection for the occurrence of azole resistance mediating cyp51 A key mutations. Using two established, a modified and a novel polymerase chain reaction (PCR) assays followed by DNA...
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